Diabetes mellitus (DM) is a major health concern caused by either insufficient insulin production (type 1 diabetes, T1DM) or the body’s inability to use insulin effectively (type 2 diabetes, T2D). Recently, stem cell-based therapy has shown considerable promise as a futuristic option. There are over 400 million people who suffer from Diabetes mellitus in 2014, and these numbers have grown steadily. It is predicted that about 600 million could have it by 2045. Currently, the treatment option being given to patients is insulin therapy, to control the blood sugar, but unfortunately, it is not capable of preventing further complications, and it can also cause other issues like hypoglycemia. The quest for better treatment is geared towards the study of the effective use of Stem Cell therapy for diabetes. The potential use of stem-cell-derived extracellular vesicles. Pluripotent stem cells Human pluripotent stem cells include embryonic stem cells and human induced pluripotent stem cells. E